• gnabgib 5 hours ago

    Discussion on the paper (57 points, 9 days ago, 47 comments) https://news.ycombinator.com/item?id=44131411

    • jasonthorsness 6 hours ago

      “They compared each participant’s brain activity on two separate nights — one when they consumed caffeine capsules three hours and then one hour before bedtime, and another when they took a placebo at the same times.”

      As someone who consumes lots of coffee I worry a little about that and always read caffeine articles but in this case doesn’t everyone already know caffeine right before bed is a bad idea?

      • unparagoned 5 hours ago

        Caffeine has a long half life. Some experts recommend you stop by 11am. Not everyone knows that

        • sparky_z 4 hours ago

          Shouldn't the recommendation depend on when you go to sleep, rather than a blanket recommendation for a specific time?

      • christophilus 7 hours ago

        I wonder if there’s a tolerance that builds over time which would also lead to the middle aged / older cohort being less affected than the younger one.

        • rpdillon 6 hours ago

          Not really. Caffeine tolerance builds over a period of days and dissipates over a similar period, roughly 72 hours. The article actually touches on the effect, and it has to do with a reduction of adenosine receptors in middle-aged participants.

          > “Adenosine receptors naturally decrease with age, reducing caffeine’s ability to block them and improve brain complexity, which may partly explain the reduced effect of caffeine observed in middle-aged participants,” Carrier said.

        • azaras 6 hours ago

          But, old people, who have taken coffee have good mental health, contrary to alcohol drinkers.

          • undefined 6 hours ago
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