There was a flash game I played where you did (maybe pseudo) protein folding. It gave you a desired shape and you had to pick bases to make it go together.

Once made it would give you some estimates on temperature-range etc. and you could tweak the bases to attempt to improve the temperature stability without making it go haywire.

I can't remember what it was called, but I had fun with it. I wonder what happened to it in a post Flash world.

there's zero examples of this employed successfully.