Everything around the topic of condensates, liquid-liquid phase separation, stress granules, etc. is quite interesting. And it seems like the importance of condensates and related phenomena has only been really understood within the past decade or so.
Protein condensates also play a role in several neurodegenerative diseases like ALS. See e.g. https://www.frontiersin.org/journals/cellular-neuroscience/a....
Paper title: Biomolecular condensates regulate cellular electrochemical equilibria
Summary of abstract: protein aggregates form electronegative buffer, with corresponding field extending to cell wall. Tested in e-coli: induced aggregates gave cell walls a negative charge, which reduced affinity to negatively-charged antibiotics.
No access to the article itself, but it's a long way from that to regulation or equilibria of any sort, so I'd be interested in reading it.
The results show that they may be a previously missing mechanism by which cells modulate their internal electrochemistry... "Our research shows that condensates influence cells well beyond direct physical contact, almost like they have a wireless connection to how cells interact with the environment,"
Dang, I thought maybe someone had figured out what the vault organelle[0] is for. Not too disappointed though, this still sounds crazy.
That said, did anyone else have a really hard time parsing this article?
You might find this interesting: https://www.rcsb.org/3d-view/4V60/1 Scroll down the menu on the sidebar (components->...), there are all kinds of "view modes" which allow you to look at different aspects of its substructure.
This is not discussing vaults.
Yes, that much I was able to parse.